Peptide Library and Peptide Array Released by Creative Peptides as Useful Tools
NEW YORK: One of the world's leading peptide suppliers, the New York-based company Creative Peptides recently announced the release of peptide library and peptide array, providing powerful tools for scientists who are involved with protein–protein interaction research, drug R&D and many other possible applications associated with biochemicals and pharmaceuticals.
Compound screening using libraries and arrays is a well-established practice. The composing elements of arrays and libraries, including small organic compounds, DNA, proteins and peptides, can be accommodated to specific needs as required in different projects. This high-throughput method primarily aims for detecting and exploring relationship between structure and function for proteins. Among its various applications, the most commonly seen include protein-protein interactions, carbohydrate arrays, epitope mapping, and enzyme binding.
Peptide array libraries usually contain partly overlapping peptides, which are derived from the sequence of one protein coming from the complex to be studied. Scientists can attach theses overlapping peptides to a solid support using a wide range of techniques like SPOT-synthesis and photolithography. After that, the array is incubated with the partner protein from the complex of interest. The last step is to detect the protein-bound peptides using immunodetection assays. All these studies are helpful in improving our fundamental understanding of cellular processes. Moreover, the relevant research findings can then serve as a basis for the design of drugs that inhibit or activate the target protein-protein interactions.
In terms of techniques used to create peptide libraries, the most widely adopted are solid-phase peptide synthesis and phage display. After years of efforts in peptide library design, up till now Creative Peptides have established wide varieties of peptide libraries, which are intended for separating minimal length active peptide sequences, for identifying critical amino acid residues, and for designing sequence-optimized analogs, etc.
